Code: BIOL-412
Semester: G
Course Type: Elective
ECTS units: 4

Instructor

Associate Professor: George Zachos
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Office Phone Number: +30 2810 394365
Lab Phone Number: +30 2810 394380

Description

Objectives of the course (preferably expressed in terms of learning outcomes and competences):  To understand the cell biology of carcinogenesis and learn about recent advances in cancer therapy.

Course contents: Introduction in tumourigenesis: proto-oncogenes, oncogenes and oncosupressors; mutagenesis, immortalisation and carcinogenesis; cell cycle control in vertebrate cells; The mitotic spindle checkpoint; Membrane receptors and signal transduction pathways: the ERK, JNK p38MAPK and PI3 kinase pathways; Chromatin remodelling in carcinogenesis; DNA damage and responses;  DNA repair pathways: mismatch repair, nucleotide excision repair, base excision repair, homologous recombination and non-homologous end-joining;  Programmed cell death;  Replicative senescence; Recent advances in cancer therapy.